Ertel W, Friedl H P, Trentz O
Department of Surgery, University of Zurich Medical School, Switzerland.
Eur J Pediatr Surg. 1994 Aug;4(4):243-8. doi: 10.1055/s-2008-1066112.
The multiple organ dysfunction syndrome (MODS) represents the number one cause of death in surgical intensive care units. It is divided into a primary and a secondary MODS based on time of manifestation and pathophysiologic events which attribute to it. The therapy of the primary MODS includes sufficient and quick resuscitation, adequate oxygen delivery and early enteral nutrition to reduce or avoid the incidence of bacterial translocation. In addition, a reduction of the "antigenic load" by control of hemorrhage, radical wound debridement, decompression, and fixation of long bone fractures appears to be effective in reducing the occurrence of MODS. The treatment of the secondary MODS remains supportive and its prevention is essential. Further studies are necessary to evaluate the clinical significance of new therapeutic agents such as monoclonal antibodies or cytokine receptor antagonists.
多器官功能障碍综合征（MODS）是外科重症监护病房中首要的死亡原因。根据其出现时间和病理生理事件，可分为原发性和继发性MODS。原发性MODS的治疗包括充分快速的复苏、充足的氧输送以及早期肠内营养，以减少或避免细菌移位的发生。此外，通过控制出血、彻底清创、减压以及固定长骨骨折来降低“抗原负荷”，似乎对减少MODS的发生有效。继发性MODS的治疗仍以支持治疗为主，预防至关重要。有必要进一步研究评估单克隆抗体或细胞因子受体拮抗剂等新型治疗药物的临床意义。
