Vashanov G A, Artiukhov V G
Biofizika. 1994 Jul-Aug;39(4):571-5.
Basic indices of oxygen-binding properties of the human hemoglobin solutions modified by the UV-light (240-390 nm) in dose range 151-604 J/m2 together with serotonin (10(-5)-10(-3) mol/l) have been analysed by means of spectrophotometry registration of the oxyhemoglobin dissociation curves. In these conditions biogenic amine displays maximum photoprotective effect at the concentration 4 x 10(-4) mol/l. At the highest concentrations serotonin exert photosensibilitive that influences the course of the protein molecule disorganisation. It has been demonstrated that three-dimensional surfaces analysis can be used to forecast the influence of the serotonin photoprotection on the hemoglobin functional activity.
通过对氧合血红蛋白解离曲线进行分光光度法记录，分析了在剂量范围为151 - 604 J/m²的紫外线（240 - 390 nm）以及血清素（10⁻⁵ - 10⁻³ mol/l）作用下，人血红蛋白溶液的氧结合特性基本指标。在这些条件下，生物胺在浓度为4×10⁻⁴ mol/l时表现出最大的光保护作用。在最高浓度时，血清素具有光敏作用，影响蛋白质分子的解体过程。已经证明，三维表面分析可用于预测血清素光保护对血红蛋白功能活性的影响。
