Obratsov V V, Tarakhovskiĭ Iu S, Ponomarchuk V V, Sklifas A N
Biofizika. 1994 Jul-Aug;39(4):732-7.
Intravenous administration of emulsions of some perfluorochemicals (PFCs) are followed by lung gas-exchange alterations, lung inflation and animal death. The emulsion toxicity can be caused by both low aggregation stability of the emulsion in the blood stream and appearance of the additional gas pressure in alveoli as a result of difference in the rates of alveolar gas and PFC vapor diffusion. Theoretical and experimental analysis shows that (1) absence of emulsion particle aggregation into blood stream, (2) low pressure of saturated vapors of PFC phase and (3) relatively low rate of PFC expiration from the organism are essential conditions for the creation of a safe fluorocarbon blood substitutes.
静脉注射某些全氟化合物（PFCs）乳剂后，会出现肺气体交换改变、肺膨胀和动物死亡。乳剂毒性可能是由于乳剂在血流中的聚集稳定性低，以及由于肺泡气体与PFC蒸汽扩散速率不同导致肺泡中出现额外气压所致。理论和实验分析表明，（1）乳剂颗粒在血流中不聚集，（2）PFC相饱和蒸汽压低，（3）PFC从机体排出的速率相对较低，是制备安全的氟碳血液代用品的必要条件。
