Enantiomeric separation of amide derivatives of some 2-arylpropionic acids by HPLC on a cellulose-based chiral stationary phase.

作者信息

Van Overbeke A, Baeyens W, Van den Bossche W, Dewaele C

机构信息

Laboratory of Drug Analysis, Faculty of Pharmaceutical Sciences, University of Ghent, Belgium.

出版信息

J Pharm Biomed Anal. 1994 Jul;12(7):911-6. doi: 10.1016/0731-7085(94)e0012-p.

A reversed phase high-performance liquid chromatographic method has been developed for the determination of the R- and S-enantiomers of ibuprofen, flurbiprofen, ketoprofen and tiaprofenic acid. Separation has been achieved using a tris(4-methylbenzoate)cellulose phase after derivatization into their amides. Flurbiprofen could also be partially resolved into its enantiomers without prior derivatization.