Porkka K V, Viikari J S, Rönnemaa T, Marniemi J, Akerblom H K
Third Department of Medicine, University of Helsinki, Finland.
Acta Paediatr. 1994 Aug;83(8):838-48. doi: 10.1111/j.1651-2227.1994.tb13155.x.
We present fractile data on serum lipids and apolipoproteins A-l and B for children and young adults from the cardiovascular risk in young Finns study cohort of 1986. The sample comprised 2370 fasting children and young adults (1114 males and 1256 females) aged 9, 12, 15, 18, 21 and 24 years. The determinations were performed in duplicate with standard methods. LDL-cholesterol values were calculated. The limits for clearly pathological values (exceeding the 97.5th percentile) irrespective of age and gender were 7.5 mmol/l, 5.0 mmol/l, 3.5 mmol/l and 1.4 g/l for serum total cholesterol, LDL-cholesterol, triglycerides and apolipoprotein B, respectively. Corresponding values (below the 2.5th percentile) for HDL-cholesterol, apolipoprotein A-l, HDL2- and HDL3-cholesterol were 0.80 mmol/l, 1.0 mg/l, 0.20 mmol/l and 0.70 mmol/l, respectively. Approximately 79%, 33% and 7% of males had serum total cholesterol values greater than 4.0 mmol, 5.0 mmol/l and 6.0 mmol/l, respectively. Corresponding percentages for females were 87%, 43% and 10%. However, age-related differences were marked. The prevalence of values, e.g. greater than 6 mmol/l according to age, ranged from 6 to 13% in females and from 3 to 12% in males, emphasizing the need for age-specific reference values. Additionally, postpubertal values for total and LDL-cholesterol tended to be slightly lower compared to prepubertal values, indicating that the reference values for adults do not apply to adolescents and young adults. The age-related changes in lipid levels were evident in each fractile and were especially accentuated in higher fractiles. Fluctuations with age were more pronounced in males than in females. These results are intended to be applied as reference values for diagnosing dyslipidemias.
我们提供了1986年芬兰年轻人心血管疾病风险研究队列中儿童和年轻人血清脂质、载脂蛋白A-1和B的分位数数据。样本包括2370名9岁、12岁、15岁、18岁、21岁和24岁的空腹儿童和年轻人（1114名男性和1256名女性）。测定采用标准方法重复进行。计算低密度脂蛋白胆固醇值。无论年龄和性别，明显病理性值（超过第97.5百分位数）的界限分别为血清总胆固醇7.5 mmol/l、低密度脂蛋白胆固醇5.0 mmol/l、甘油三酯3.5 mmol/l和载脂蛋白B 1.4 g/l。高密度脂蛋白胆固醇、载脂蛋白A-1、高密度脂蛋白2胆固醇和高密度脂蛋白3胆固醇的相应值（低于第2.5百分位数）分别为0.80 mmol/l、1.0 mg/l、0.20 mmol/l和0.70 mmol/l。分别约有79%、33%和7%的男性血清总胆固醇值大于4.0 mmol/l、5.0 mmol/l和6.0 mmol/l。女性的相应百分比分别为87%、43%和10%。然而，年龄相关差异明显。例如，根据年龄大于6 mmol/l的值的患病率在女性中为6%至13%，在男性中为3%至12%，强调了需要特定年龄的参考值。此外，青春期后总胆固醇和低密度脂蛋白胆固醇值往往略低于青春期前值，表明成人参考值不适用于青少年和年轻人。脂质水平的年龄相关变化在每个分位数中都很明显，在较高分位数中尤为突出。男性随年龄的波动比女性更明显。这些结果旨在用作诊断血脂异常的参考值。
