Kokileva L
Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia.
Int Arch Allergy Immunol. 1994 Dec;105(4):339-43. doi: 10.1159/000236779.
Elucidation of the mechanism and regulation of cell destruction in apoptosis requires knowledge of genome degradation. The cell genome, which encodes the fundamental cell programmes, is most likely to be the main sensitive target in cell apoptosis. Genome breakdown may be achieved by the generation and transduction of apoptogenic signal information to the specific chromatin regions of the nucleus, thus inactivating the basic cell programmes and inducing the endogenous pattern of chromatin degradation, which is determined by the genome organization of the eukaryotic nuclei. Detachment of chromatin from the nuclear matrix attachment regions may be one of the possible mechanisms of switching off the genome function and triggering the multi-step process of endogenous chromatin degradation, thus leading to cell death of terminal differentiation or stress-induced apoptosis.
阐明细胞凋亡中细胞破坏的机制和调控需要了解基因组降解。编码基本细胞程序的细胞基因组很可能是细胞凋亡中的主要敏感靶点。基因组的分解可能通过凋亡信号信息的产生和转导至细胞核的特定染色质区域来实现，从而使基本细胞程序失活并诱导由真核细胞核基因组组织决定的内源性染色质降解模式。染色质从核基质附着区域的脱离可能是关闭基因组功能并触发内源性染色质降解多步骤过程的可能机制之一，从而导致终末分化或应激诱导凋亡的细胞死亡。
