Winoto A
Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200.
Int Arch Allergy Immunol. 1994 Dec;105(4):344-6. doi: 10.1159/000236780.
One of the in vitro model of programmed cell death is T cell receptor (TCR)-mediated apoptosis of immature T cells and T cell hybridomas. This form of apoptosis requires newly gene synthesis and may relate to negative selection during T cell development. Recently, an orphan steroid receptor Nur77 was found to be induced during TCR-mediated apoptosis. When introduced into T cells, a dominant negative or antisense Nur77 construct can block the apoptosis process. Various inhibitors of TCR-mediated apoptosis, including cyclosporin A down-regulate the Nur77 DNA binding activity. Thus, the Nur77 protein family may play a crucial role during T cell apoptosis.
程序性细胞死亡的体外模型之一是T细胞受体（TCR）介导的未成熟T细胞和T细胞杂交瘤的凋亡。这种凋亡形式需要新的基因合成，并且可能与T细胞发育过程中的阴性选择有关。最近，发现一种孤儿类固醇受体Nur77在TCR介导的凋亡过程中被诱导。当将显性阴性或反义Nur77构建体导入T细胞时，可阻断凋亡过程。TCR介导的凋亡的各种抑制剂，包括环孢菌素A，可下调Nur77的DNA结合活性。因此，Nur77蛋白家族可能在T细胞凋亡过程中起关键作用。
