Drzewoski J, Pierściński G, Nowak D
Department of Clinical Pharmacology, School of Pharmacology, Medical Academy, Lódź, Poland.
Pol J Pharmacol. 1994 Jan-Apr;46(1-2):51-4.
The purpose of this study was to evaluate in vivo the influence of doxorubicin (DOX) and its less cardiotoxic analog 4'-epi-doxorubicin (EPI) on lipid peroxidation. The content of conjugated dienes (CD) in heart, liver and lungs of Balb/c mice was measured over a 24-h period at various time-points [1.5 and 24 h] after a single intravenous injection of either DOX or EPI. A statistically significant (p < 0.01) increase in CD levels was seen in mice heart extracts 24 h after treatment with DOX. No statistically significant increase in CD content was seen in any other group of animals treated with either DOX or EPI up to 24 h. The data presented in this paper indicate that DOX, but not EPI, induces lipid peroxidation in cardiac muscle.
本研究的目的是在体内评估阿霉素（DOX）及其心脏毒性较小的类似物4'-表阿霉素（EPI）对脂质过氧化的影响。在单次静脉注射DOX或EPI后的不同时间点[1.5小时和24小时]，在24小时内测量Balb/c小鼠心脏、肝脏和肺中共轭二烯（CD）的含量。用DOX治疗24小时后，小鼠心脏提取物中的CD水平出现统计学显著升高（p < 0.01）。在使用DOX或EPI治疗的任何其他动物组中，直至24小时，CD含量均未出现统计学显著升高。本文提供的数据表明，DOX而非EPI可诱导心肌中的脂质过氧化。
