Byrd J A, Dean C E, Hargis B M
Department of Poultry Science, Texas A & M University System, College Station 77843.
Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 1994 Jul;108(2):221-7. doi: 10.1016/1367-8280(94)90034-5.
Utilizing avian, porcine and canine adrenocortical cells, we have examined the effect of bursal anti-steroidogenic peptide (BASP) on adrenocorticotropin (ACTH) and dibutyryl cyclic AMP (DB-cAMP)-stimulated corticosteroid and cAMP formation. BASP significantly (P < 0.05) suppressed corticosteroid production from adrenocortical cells derived from chickens, pigs and dogs. BASP significantly increased cAMP formation (up to 10-fold) in a dose-related manner. These findings suggest that BASP structure and activity may be conserved between chicken, porcine and canine species.
