McLoughlin R F, Mathieson J R, Chipperfield P M, Grymaloski M R, Wong A D
Department of Radiology, St. Paul's Hospital, Vancouver, BC.
Can Assoc Radiol J. 1994 Dec;45(6):452-4.
Hyoscine butylbromide (Buscopan) is an intravenously administered hypotonic agent that significantly reduces pressure in the lower esophageal sphincter and may therefore artificially induce gastroesophageal reflux during barium examination of the upper gastrointestinal tract. This study was performed to test this hypothesis. The presence or absence and severity of gastroesophageal reflux before and after intravenous injection of 20 mg Buscopan were evaluated in 112 consecutive patients undergoing biphasic upper gastrointestinal examination. Gastroesophageal reflux was seen in 49 (44%) of the patients. Reflux was evident both before and after the injection of Buscopan in 35 (31%) of the patients, before injection only in 10 (9%) and after injection only in 4 (4%). The magnitude of reflux after injection of Buscopan was reduced or the same in 108 of the patients (96%) and increased in 4 (4%). There was no significant difference in the overall occurrence (p = 0.41) or degree (p = 0.81) of gastroesophageal reflux before and after injection of Buscopan (chi 2 test). The authors conclude that the routine use of Buscopan is unlikely to spuriously increase the frequency or degree of gastroesophageal reflux observed on upper gastrointestinal barium studies.
丁溴东莨菪碱（解痉灵）是一种静脉注射的低渗剂，可显著降低食管下括约肌压力，因此在进行上消化道钡餐检查时可能会人为诱发胃食管反流。本研究旨在验证这一假设。对112例连续接受双相上消化道检查的患者，评估静脉注射20mg丁溴东莨菪碱前后胃食管反流的有无及严重程度。49例（44%）患者出现胃食管反流。35例（31%）患者在注射丁溴东莨菪碱前后均有明显反流，仅注射前有反流的10例（9%），仅注射后有反流的4例（4%）。108例（96%）患者注射丁溴东莨菪碱后反流程度减轻或不变，4例（4%）患者反流程度增加。注射丁溴东莨菪碱前后胃食管反流的总体发生率（p = 0.41）或程度（p = 0.81）无显著差异（卡方检验）。作者得出结论，常规使用丁溴东莨菪碱不太可能在进行上消化道钡餐检查时假性增加胃食管反流的频率或程度。
