Sau F, Seguro C, Pargentino E
Istituto di Cardiologia, Università degli Studi, Cagliari.
Cardiologia. 1994 Jul;39(7):473-9.
To define the time course of regression of left ventricular hypertrophy (LVH) during antihypertensive therapy with beta-blocking agents, 73 hypertensive patients were serially studied by echocardiography during 12-months therapy with beta-blockers. Blood pressure decreased significantly after 1 month and further on after 12 months (from 164 +/- 18/110 +/- 9 to 139 +/- 14/94 +/- 7 mmHg, p < 0.001). Left ventricular (LV) end-diastolic dimension increased significantly after 1 month (from 51.2 +/- 3.9 to 52.2 +/- 4.7 mm, p < 0.01) and decreased after 12 months (50.4 +/- 4.0 mm, p < 0.05). Septal and posterior wall thickness decreased progressively after 1 month and 3 months, respectively. LV mass index decreased significantly after 3 months, and further on after 12 months (from 164 +/- 42 to 145 +/- 33 g/m2, p < 0.001). LV fractional shortening did not significantly change throughout the study. Thus, a reduction of hypertensive LVH occurred after 3 months of therapy with beta-blocking agents and went on during the subsequent months without impairment of LV systolic function.
为了确定使用β受体阻滞剂进行抗高血压治疗期间左心室肥厚（LVH）消退的时间进程，在73例高血压患者接受β受体阻滞剂12个月治疗期间，通过超声心动图对其进行了连续研究。治疗1个月后血压显著下降，12个月后进一步下降（从164±18/110±9降至139±14/94±7 mmHg，p<0.001）。左心室（LV）舒张末期内径在1个月后显著增加（从51.2±3.9增加到52.2±4.7 mm，p<0.01），12个月后减小（50.4±4.0 mm，p<0.05）。室间隔和后壁厚度分别在1个月和3个月后逐渐减小。LV质量指数在3个月后显著下降，12个月后进一步下降（从164±42降至145±33 g/m2，p<0.001）。在整个研究过程中，LV缩短分数没有显著变化。因此，使用β受体阻滞剂治疗3个月后发生了高血压性LVH的减轻，并在随后的几个月中持续减轻，而LV收缩功能未受损。
