Jaeger K E
Lehrstuhl für Biologie der Mikroorganismen, Fakultät für Biologie der Ruhr-Universität Bochum.
Immun Infekt. 1994 Oct;22(5):177-80.
Pseudomonas aeruginosa is an opportunistic pathogen causing a variety of diseases, especially in immunocompromised patients like those suffering from cystic fibrosis (CF) where these bacteria preferentially colonize the bronchopulmonary tract. A high intrinsic antibiotic resistance and its ability to synthesize and secrete numerous different virulence factors are regarded as biological properties contributing to the pathogenicity of P. aeruginosa. Among the virulence factors are many enzymes which have been characterized in detail with respect to their molecular properties. Environmental factors regulating the synthesis and release of extracellular enzymes have been identified as e.g. the concentration of Fe- and PO4-ions, choline, pH, and osmolarity. In addition, low molecular weight substances named autoinducers were identified as regulators which are synthesized by the bacteria. Therefore, P. aeruginosa represents an example for the remarkably complex relationship between pathogenic bacteria and their human host.
铜绿假单胞菌是一种机会致病菌，可引发多种疾病，尤其是在免疫功能低下的患者中，如患有囊性纤维化（CF）的患者，这些细菌优先定植于支气管肺部。其高度的内在抗生素耐药性以及合成和分泌多种不同毒力因子的能力被视为有助于铜绿假单胞菌致病性的生物学特性。在毒力因子中，有许多酶已就其分子特性进行了详细表征。已确定调节细胞外酶合成和释放的环境因素，例如铁离子和磷酸根离子的浓度、胆碱、pH值和渗透压。此外，被称为自诱导物的低分子量物质被确定为由细菌合成的调节因子。因此，铜绿假单胞菌代表了病原菌与其人类宿主之间极其复杂关系的一个例子。
