Someya Y, Fukumoto H, Seino Y
Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine.
Nihon Rinsho. 1994 Oct;52(10):2562-7.
The high Km glucose transporter, termed GLUT2, is expressed in pancreatic beta-cells and hepatocytes in a tissue specific manner. Previous studies revealed that higher glucose levels cause increased GLUT2 gene expression in beta-cells and hepatocytes and that 11 exons of human GLUT2 gene are spanning around 30 kilobases in q26.1-->q26.3 region of was has been chromosome 3. While the putative transcriptional start site has been reported, we made a series of deletion analyses of the human GLUT2 gene promoter region and showed that the sequences located downstream of the putative transcriptional start site are essential for transcription not only in a hamster beta-cell line but also in primary cultured rat hepatocytes.
高Km葡萄糖转运体，即GLUT2，以组织特异性方式在胰腺β细胞和肝细胞中表达。先前的研究表明，较高的葡萄糖水平会导致β细胞和肝细胞中GLUT2基因表达增加，并且人类GLUT2基因的11个外显子跨越3号染色体q26.1→q26.3区域约30千碱基。虽然已经报道了推定的转录起始位点，但我们对人类GLUT2基因启动子区域进行了一系列缺失分析，结果表明，推定转录起始位点下游的序列不仅对仓鼠β细胞系，而且对原代培养的大鼠肝细胞的转录都是必不可少的。
