Kadowaki H, Kadowaki T
Institute for Diabetes Care and Research, Asahi Life Foundation.
Nihon Rinsho. 1994 Oct;52(10):2648-52.
Many clinical observations have suggested that there is a strong relationship between hyperinsulinemia and hyperandrogenism. HAIR-AN syndrome is defined as a constellation of hyperandrogenism (HA), insulin resistance (IR), and acanthosis nigricans (AN). Two major mechanisms could account for this syndrome: (i) hyperinsulinemia induced by insulin resistance causes hyperandrogenism, and (ii) hyperandrogenism causes insulin resistance and hyperinsulinemia. Acanthosis nigricans is considered to be an epiphenomenon caused by hyperinsulinemia. The causes of HAIR-AN syndrome include syndromes of extreme insulin resistance due to mutations in the insulin receptor gene, lipoatrophic diabetes, obesity, some endocrinopathies, and genetic and acquired ovarian hyperandrogenism.
许多临床观察表明，高胰岛素血症与高雄激素血症之间存在密切关系。HAIR-AN综合征被定义为高雄激素血症（HA）、胰岛素抵抗（IR）和黑棘皮症（AN）的一组症状。该综合征可能有两种主要机制：（i）胰岛素抵抗诱导的高胰岛素血症导致高雄激素血症，以及（ii）高雄激素血症导致胰岛素抵抗和高胰岛素血症。黑棘皮症被认为是高胰岛素血症引起的一种附带现象。HAIR-AN综合征的病因包括胰岛素受体基因突变导致的极度胰岛素抵抗综合征、脂肪萎缩性糖尿病、肥胖、某些内分泌疾病以及遗传性和后天性卵巢高雄激素血症。
