López-Sañudo S, Arilla E
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Alcalá, Madrid, Spain.
Brain Res Mol Brain Res. 1994 Aug;25(1-2):143-6. doi: 10.1016/0169-328x(94)90290-9.
The administration of an alpha 2-adrenoceptor agonist, clonidine, increased the number of somatostatin (SS) receptors and the affinity constant in frontoparietal cortex membranes. In addition, in the clonidine group, the capacity of SS to inhibit basal and forskolin (FK)-stimulated adenylyl cyclase (AC) activity in the frontoparietal cortex was significantly higher than in the control group. Pretreatment with the alpha 2-adrenoceptor antagonist yohimbine prevented the clonidine-induced changes in SS binding and SS-inhibited AC activity. Yohimbine alone had an opposite effect from clonidine. These experiments provide further evidence that the alpha-adrenergic system modulates the rat frontoparietal cortex somatostatinergic system.
给予α2 -肾上腺素能受体激动剂可乐定可增加大鼠额顶叶皮质膜中生长抑素（SS）受体的数量及其亲和常数。此外，在可乐定组中，SS抑制额顶叶皮质基础及福斯可林（FK）刺激的腺苷酸环化酶（AC）活性的能力显著高于对照组。用α2 -肾上腺素能受体拮抗剂育亨宾预处理可阻止可乐定诱导的SS结合及SS抑制的AC活性的变化。单独使用育亨宾的作用与可乐定相反。这些实验进一步证明，α -肾上腺素能系统对大鼠额顶叶皮质生长抑素能系统具有调节作用。
