大鼠视网膜中γ-氨基丁酸A（GABAA）受体α1亚基和L-谷氨酸脱羧酶（GAD）mRNA的表达与定位：原位杂交分析

Expression and localization of gamma-aminobutyric acid A (GABAA) receptor alpha 1 subunit and L-glutamate decarboxylase (GAD) mRNAs in rat retina: an analysis by in situ hybridization.

作者信息

Kosaka J, Morii E, Taniguchi M, Kitamura Y, Nomura S, Fukuda Y

机构信息

Department of Physiology, Osaka University Medical School, Japan.

出版信息

Brain Res Mol Brain Res. 1994 Aug;25(1-2):163-7. doi: 10.1016/0169-328x(94)90294-1.

DOI:10.1016/0169-328x(94)90294-1

PMID:7984044

Abstract

The localization of the mRNAs encoding gamma-aminobutyric acidA receptor alpha 1 subunit (GABAA alpha 1) and L-glutamate decarboxylase (GAD) was elucidated in the rat retina by in situ hybridization. Soma diameter analysis of signal positive cells in the ganglion cell layer demonstrated that a subpopulation including alpha-cells of retinal ganglion cells expressed GABAA alpha 1 mRNA and a subpopulation of ganglion cells smaller than alpha-cells expressed GAD mRNA.

摘要

通过原位杂交技术在大鼠视网膜中阐明了编码γ-氨基丁酸A受体α1亚基（GABAAα1）和L-谷氨酸脱羧酶（GAD）的mRNA的定位。对神经节细胞层中信号阳性细胞的胞体直径分析表明，包括视网膜神经节细胞α细胞在内的一个亚群表达GABAAα1 mRNA，而小于α细胞的神经节细胞亚群表达GAD mRNA。