Gonawardena S A, Ranasinghe K P, Arseculeratne S N, Seimon C R, Ajello L
Department of Microbiology, University of Peradeniya, Sri Lanka.
Mycopathologia. 1994 Aug;127(2):77-81. doi: 10.1007/BF01103062.
Over a two-year period (1976-1977 and 1980-1981), 66 cases of bacterial and mycotic cases of keratitis were diagnosed in the Eye Clinic of the General Hospital in Kandy, Sri Lanka. The clinical and microbiologic aspects of these cases are described. Noteworthy was the first known human case caused by Paecilomyces farinosus, a geophilic species, commonly encountered as an insect parasite throughout the world. The bacterial and the other fungal etiologic agents isolated and identified were: Pseudomonas aeruginosa, Streptococcus pneumoniae, Aspergillus flavus, A. niger, Fusarium oxysporum, and Lasiodiplodia theobromae. In vitro the fungi showed sensitivity in decreasing order to flucytosine, nystatin, amphotericin B and econazole. Due to the out-patient status of the patients, their in-vivo response to treatment was not assessable.
在两年期间（1976 - 1977年和1980 - 1981年），斯里兰卡康提总医院眼科门诊诊断出66例细菌性和霉菌性角膜炎病例。本文描述了这些病例的临床和微生物学特征。值得注意的是，首次发现了由嗜土曲霉引起的人类病例，这种真菌在世界各地普遍作为昆虫寄生虫存在。分离和鉴定出的细菌及其他真菌病原体有：铜绿假单胞菌、肺炎链球菌、黄曲霉、黑曲霉、尖孢镰刀菌和可可毛色二孢。体外实验中，这些真菌对氟胞嘧啶、制霉菌素、两性霉素B和益康唑的敏感性依次降低。由于患者为门诊患者，无法评估他们对治疗的体内反应。
