小鼠肥胖基因及其人类同源基因的定位克隆。
Positional cloning of the mouse obese gene and its human homologue.
作者信息
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J M
机构信息
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021.
出版信息
Nature. 1994 Dec 1;372(6505):425-32. doi: 10.1038/372425a0.
The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation of ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
平衡食物摄入与能量消耗的机制决定了谁会肥胖，谁会消瘦。调节小鼠能量平衡的分子之一是肥胖（ob）基因。ob基因发生突变会导致严重肥胖和II型糖尿病，这是一种类似于人类病态肥胖的综合征的一部分。ob基因产物可能作为脂肪组织信号通路的一部分发挥作用，该信号通路用于调节身体脂肪储备的大小。
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