[Regulation of pancreatic glucagon secretion].

Intensive investigations during the last few years have shown that the regulation of the secretion of pancreatic glucagon is controlled by nerval, humoral and metabolic factors. Of decisive importance is the actually present glucose level which by inhibition modifies the effectiveness of the most different stimulators (intestinal hormones, amino acids). In addition to this the hormones insulin and somatostatin formed by the islets of Langerhans of the pancreas seem to be of importance for the local reactivity of the A-cells of the endocrine pancreas. Disturbances of the glucagon secretion of the pancreas have been found in different diseases connected with hyperglycaemia (especially in diabetes mellitus). The review tried to summarize our present knowledge of the physiology and pathophysiology in this field.