Adambekov D A
Probl Tuberk. 1993(2):51-3.
The role of T-lymphocyte subpopulations in regulation of immunity was studied using monoclonal antibodies OKT-4 and OKT-8 in tuberculous patients and healthy subjects of different age. Basing on the examination of 174 patients, it was established that in older subjects pulmonary tuberculosis runs in the presence of aged-related changes in the immune system: an increase in the number of T-suppressors, a reduction in that of T-helpers, secondary immunodeficiency dependent on the process severity and forms. These shifts are suggested to be responsible for the inadequate immune response to M. tuberculosis in the elderly.
利用单克隆抗体OKT - 4和OKT - 8对不同年龄的结核病患者和健康受试者进行研究，以探讨T淋巴细胞亚群在免疫调节中的作用。基于对174例患者的检查发现，老年受试者患肺结核时存在与年龄相关的免疫系统变化：T抑制细胞数量增加，T辅助细胞数量减少，继发性免疫缺陷取决于病情严重程度和类型。这些变化被认为是老年人对结核分枝杆菌免疫反应不足的原因。
