Krylov V A, Titov V F, Tereshin V S
Probl Tuberk. 1994(4):41-4.
Two procedures for treating experimental tuberculosis were compared. One comprised a rapid administration of tuberculin up to large doses (20,000 TE), the other included weakly stimulating therapy with tuberculin (its maximum dose being 150 TE). Treatment with tuberculin in combination with isoniazid ensures a higher resolution of specific abnormalities than that with isoniazid alone. However, when either procedures were used, the weakly stimulating procedure led to experimental animals' death, which generates the need to take a preliminary account of the body's response to tuberculin in the clinical setting in order to choose tuberculin therapy on an individual basis.
对两种治疗实验性结核病的方法进行了比较。一种方法是快速给予大剂量（20,000结核菌素单位）的结核菌素，另一种方法是用结核菌素进行弱刺激疗法（最大剂量为150结核菌素单位）。与单独使用异烟肼相比，结核菌素联合异烟肼治疗能使特定异常情况得到更高的缓解率。然而，无论采用哪种方法，弱刺激疗法都会导致实验动物死亡，这就需要在临床环境中预先考虑机体对结核菌素的反应，以便进行个体化的结核菌素治疗选择。
