Kaminskaia G O, Grigoréva E V
Probl Tuberk. 1994(4):5-8.
The plasma levels of immunoreactive fibronectin (IRF) and its functionally full-value fraction (FVF) were estimated from the capacity to bind to heparin to form a cold precipitate in 86 patients with various types of active pulmonary tuberculosis on admission, 1, 2-3, and 4-6 months after multimodality treatment. Active pulmonary tuberculosis was found to be accompanied by an acute phasic increase in IRF, which was masked by its increased uptake and regularly detected at early stages of chemotherapy. The levels of FVF sharply dropped. A follow-up of IRF and FVF levels during treatment permits the monitoring of the magnitude of biological effects.
通过检测86例不同类型活动性肺结核患者入院时、多模式治疗后1个月、2 - 3个月以及4 - 6个月时血浆中免疫反应性纤连蛋白（IRF）及其功能全值组分（FVF）与肝素结合形成冷沉淀的能力，对其进行了评估。发现活动性肺结核伴有IRF急性阶段性升高，这一升高因IRF摄取增加而被掩盖，且在化疗早期可被常规检测到。FVF水平急剧下降。治疗期间对IRF和FVF水平进行随访有助于监测生物学效应的大小。
