Juckel G, Hegerl U
Department of Psychiatry, Free University of Berlin, Germany.
Pharmacopsychiatry. 1994 Jul;27 Suppl 1:27-9. doi: 10.1055/s-2007-1014323.
The link between suicidality and serotonergic dysfunction is a consistent finding in biological psychiatry. In three independent studies we found weak intensity dependence of auditory evoked potentials, which may be related to high serotonergic activity, in psychiatric patients with a history of suicide attempts. This result seems to contradict studies reporting low serotonergic activity in acute suicidal patients. As an explanation for this discrepancy we propose that serotonergic activity may be low only in acute suicidal states, and that high serotonergic activity, as reflected by a weak intensity dependence, may characterize high-risk patients, in whom a transient decrease of serotonergic activity is accompanied by acute suicidality.
自杀倾向与血清素能功能障碍之间的联系是生物精神病学中一个一致的发现。在三项独立研究中，我们发现有自杀未遂史的精神病患者听觉诱发电位的强度依赖性较弱，这可能与高血清素能活性有关。这一结果似乎与报告急性自杀患者血清素能活性较低的研究相矛盾。作为对这种差异的一种解释，我们提出血清素能活性可能仅在急性自杀状态下较低，而强度依赖性较弱所反映的高血清素能活性可能是高危患者的特征，在这些患者中，血清素能活性的短暂下降伴随着急性自杀倾向。
