糖皮质激素性骨质疏松症
Glucocorticoid-induced osteoporosis.
作者信息
Lukert B P, Raisz L G
机构信息
University of Kansas Medical Center, Kansas City.
出版信息
Rheum Dis Clin North Am. 1994 Aug;20(3):629-50.
PMID:7984782
Abstract
Glucocorticoids are important in the management of rheumatic diseases. Bone loss is one of the most devastating side effects of glucocorticoids because they inhibit calcium transport, cause secondary hyperparathyroidism, hypogonadism, and impairment of osteoblast function. Efforts to control these side effects minimize bone loss.
摘要
糖皮质激素在风湿性疾病的治疗中很重要。骨质流失是糖皮质激素最具破坏性的副作用之一，因为它们会抑制钙的转运，导致继发性甲状旁腺功能亢进、性腺功能减退和成骨细胞功能受损。控制这些副作用的努力可将骨质流失降至最低。
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