Gavira R, Gómez F, Otero M J, Barrueco M, Domínguez-Gil A
Servicio de Neumología, Hospital Universitario, Salamanca.
Rev Clin Esp. 1994 Sep;194(9):677-81.
Tuberculosis is a first magnitude sanitary problem with several factors that make difficult its eradication, among these are particularly important those derived from the antituberculous therapy: noncompliance and adverse reactions to the drugs used. We have developed a follow-up program for ambulatory patients with antituberculous therapy that includes compliance control and systematical survey or possible adverse reactions. We expose our results after its application to 39 patients with tuberculosis and 24 with tuberculous infection. The compliance level among patients with tuberculous disease was 100% and among those who were receiving chemoprophylaxis 75%, both values much higher than those found in the literature. We detected adverse reactions in 43.6% of the patients with tuberculous treatment and 37.5% of those receiving chemoprophylaxis with isoniazid. Setting up follow-up programs in antituberculous treatments notably helps to improve the compliance and the safety of treatment.
结核病是一个严重的卫生问题,有多种因素使其难以根除,其中特别重要的是抗结核治疗引发的因素:不依从性和对所用药物的不良反应。我们为接受抗结核治疗的门诊患者制定了一个随访计划,其中包括依从性控制以及对可能出现的不良反应进行系统调查。我们将该计划应用于39例结核病患者和24例结核感染患者后公布了结果。结核病患者的依从率为100%,接受化学预防的患者依从率为75%,这两个数值均远高于文献中的报道。我们在43.6%的结核病治疗患者和37.5%接受异烟肼化学预防的患者中检测到了不良反应。在抗结核治疗中建立随访计划显著有助于提高治疗的依从性和安全性。