Tazi A, Soler P, Hance A J
Service de pneumologie, hôpital Avicenne, Bobigny.
Rev Prat. 1994 Oct 1;44(15):2017-23.
Sarcoidosis is a multisystemic granulomatous disorder due to an immune response of unknown etiology. The interactions between monocytes/macrophages and T lymphocytes through direct contact between the cells play a major role in the occurrence of these responses. Factors depending on the host, such as the polymorphism of the major histocompatibility complex molecules could be implicated in sarcoidosis pathogenesis. The factors that regulate the degree of granulomatous reaction, or those that determine the degree of fibrous response observed in some patients with sarcoidosis are poorly understood. Two recent studies, using the high sensitivity of the polymerase chain reaction, have shown the presence of M. tuberculosis DNA in 13 to 50% of biopsy samples from sarcoid patients, suggesting a role of this agent in the disease, at least in certain cases.
结节病是一种病因不明的免疫反应导致的多系统肉芽肿性疾病。单核细胞/巨噬细胞与T淋巴细胞之间通过细胞直接接触的相互作用在这些反应的发生中起主要作用。宿主相关因素，如主要组织相容性复合体分子的多态性可能与结节病的发病机制有关。调节肉芽肿反应程度的因素，或决定某些结节病患者观察到的纤维化反应程度的因素尚不清楚。最近的两项研究利用聚合酶链反应的高灵敏度，在13%至50%的结节病患者活检样本中发现了结核分枝杆菌DNA，这表明该病原体在疾病中至少在某些情况下发挥了作用。
