Tupitsyn N N, Kruglova G V, Osmanov D Sh, Frenkel' M A, Baryshnikov A Iu, Sholokhova E N, Kadagidze Z G
Ter Arkh. 1994;66(7):36-9.
The authors studied a blast cell immunological phenotype in 50 adults with lymphosarcoma undergoing leukemization following the pattern of acute leukemia. Among the patients there were 12 females and 38 males aged 14-61. Immunological phenotyping of tumor cells was performed using a panel of monoclonal antibodies to T- and B-lymphocyte antigens, to myelomonocytic cells, some nonlinear and activation antigens. T, B and zero variants of blast cells were identified. Occasionally, blast cells carried nonlymphoid antigens and those corresponding to the common lymphosarcoma subvariant. Leukemization in the direction of lymphoblastic leukemia is associated with greater frequency of lymphosarcoma T subvariant (46%). B-cell and zero subvariants occurred in 28% and 20% of the patients, respectively. The number of complete remissions in the group of patients with T-cell subvariant was greater than in the group with B-cell subvariant. The survival in these two groups, however, was almost similar (median up to 8-12 months). Further studies into lymphoblastic leukemization immunophenotyping can help design programs of differentiated polychemotherapy.
作者对50例按照急性白血病模式发生白血病化的成年淋巴肉瘤患者的原始细胞免疫表型进行了研究。患者中有12名女性和38名男性，年龄在14至61岁之间。使用一组针对T和B淋巴细胞抗原、髓单核细胞、一些非淋巴细胞和激活抗原的单克隆抗体对肿瘤细胞进行免疫表型分析。确定了原始细胞的T、B和零变异型。偶尔，原始细胞携带非淋巴细胞抗原以及与常见淋巴肉瘤亚型相对应的抗原。向淋巴细胞白血病方向的白血病化与淋巴肉瘤T亚型的更高频率相关（46%）。B细胞和零亚型分别出现在28%和20%的患者中。T细胞亚型患者组的完全缓解次数多于B细胞亚型患者组。然而，这两组的生存率几乎相似（中位数高达8至12个月）。对淋巴细胞白血病化免疫表型的进一步研究有助于设计分化多药化疗方案。
