Neverov N I, Ivanov A A
Ter Arkh. 1994;66(7):73-6.
An extracellular matrix (collagens I, III, IV) was studied in the glomeruli of patients demonstrating glomerular low density lipoproteins (LDL) and free of them. These two patients' groups were not found significantly different by age, nephropathy duration, blood pressure, serum concentrations of creatinine, triglycerides, HDL cholesterol. The LDL deposit group differed by longer duration of the nephrotic syndrome, higher 24-h proteinuria, lower serum albumin levels, higher total cholesterol in the serum and the proportion VLDL and LDL cholesterol to HDL cholesterol. They had noninflammatory nephropathies more frequently, collagen IV accumulated in the glomerulus more actively, there appeared interstitial collagens I and III. The discussion concerns the role of hypercholesterolemia with the above proportion of cholesterols, its duration, a type of cells dictating mesangial proliferation, in the development of LDL-deposit-induced glomerulosclerosis.
对肾小球低密度脂蛋白（LDL）阳性和阴性患者的肾小球中的细胞外基质（I、III、IV型胶原）进行了研究。这两组患者在年龄、肾病病程、血压、血清肌酐、甘油三酯、高密度脂蛋白胆固醇浓度方面未发现显著差异。LDL沉积组的肾病综合征病程更长、24小时蛋白尿更高、血清白蛋白水平更低、血清总胆固醇以及极低密度脂蛋白和低密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比例更高。他们更常患非炎症性肾病，IV型胶原在肾小球中更活跃地积累，出现了I型和III型间质胶原。讨论了高胆固醇血症及其胆固醇比例、持续时间、决定系膜增殖的细胞类型在LDL沉积诱导的肾小球硬化发展中的作用。
