Malo D, Skamene E
McGill Centre, Montreal General Hospital, Canada.
Trends Genet. 1994 Oct;10(10):365-71. doi: 10.1016/0168-9525(94)90133-3.
Human resistance to infectious diseases is often regulated by multiple genes that control different aspects of host-parasite interaction. Genetically distinct inbred strains of mice that differ in their susceptibility to specific pathogens are invaluable for dissecting such complex patterns and have allowed the identification of several host-resistance loci that regulate natural and acquired immunity in response to infection. Cloning these genes is the first step in elucidating their roles in host defense.
人类对传染病的抵抗力通常由多个基因调控，这些基因控制着宿主与寄生虫相互作用的不同方面。对特定病原体易感性不同的遗传上有差异的近交系小鼠，对于剖析这种复杂模式非常宝贵，并已使人们鉴定出了几个调控针对感染的天然免疫和获得性免疫的宿主抗性基因座。克隆这些基因是阐明它们在宿主防御中作用的第一步。
