儿童7号染色体单体型骨髓发育异常。两例病例报告。

Monosomy 7 myelodysplasia in childhood. Two case reports.

作者信息

Yeşilipek M A, Lüleci G, Velipaşaoğlu S, Berker S, Yeğin O

机构信息

Akdeniz University Medical School, Department of Pediatric Hematology and Medical Biology, Antalya, Turkey.

出版信息

Acta Haematol. 1994;92(1):36-8. doi: 10.1159/000204135.

DOI:10.1159/000204135

PMID:7985480

Abstract

Monosomy 7 myelodysplasia is a rare hematological entity and is associated with morphological abnormalities in bone marrow and peripheral smear, and poor prognosis in children. We describe 2 children with infantile monosomy 7 myelodysplasia which evolved to leukemia. One of them died after 1 month, and the other is still on therapy for acute myelocytic leukemia (M4) which has evolved from chronic myelomonocytic leukemia. We concluded that chromosomal analysis must be done routinely in patients with myelodysplasia, in acute myeloid leukemia and chronic myelomonocytic leukemia.

摘要

7号染色体单体型骨髓发育异常是一种罕见的血液学疾病，与骨髓和外周血涂片的形态学异常以及儿童预后不良有关。我们描述了2例婴儿期7号染色体单体型骨髓发育异常并进展为白血病的患儿。其中1例在1个月后死亡，另一例仍在接受从慢性粒单核细胞白血病进展而来的急性髓细胞白血病（M4）的治疗。我们得出结论，对于骨髓发育异常、急性髓系白血病和慢性粒单核细胞白血病患者，必须常规进行染色体分析。