Hannan E L, Burke J
Department of Health Policy and Management, School of Public Health, State University of New York, Albany 12222.
Am Heart J. 1994 Dec;128(6 Pt 1):1184-91. doi: 10.1016/0002-8703(94)90750-1.
The purpose of this study was to determine the effect of age on the in-hospital mortality of all 30,972 patients undergoing coronary artery bypass graft (CABG) surgery in New York in 1991 and 1992. Mortality rates were relatively low for patients 40-49, 50-59, and 60-64, 65-69, and 70-74 years old (1.10%, 1.65%, 2.17%, 2.76%, and 3.36%, respectively). However, CABG surgery mortality increased rapidly for patients 75 to 79 years old (5.28%) and patients > or = 80 years old (8.31%). To examine the independent effect of age on mortality after accounting for the effects of other significant risk factors, a multivariate statistical model was developed to identify the significant independent predictors of mortality. Age emerged as 1 of 24 significant predictors, with age > or = 75 demonstrating much higher mortality risk than lesser age. For example, the odds of an 80-year-old patient's dying in the hospital were 3.25 times the odds of a 50-year-old patient's dying in the hospital, assuming all other significant risk factors were identical.
本研究的目的是确定年龄对1991年和1992年在纽约接受冠状动脉搭桥术(CABG)的30972例患者院内死亡率的影响。40 - 49岁、50 - 59岁、60 - 64岁、65 - 69岁和70 - 74岁患者的死亡率相对较低(分别为1.10%、1.65%、2.17%、2.76%和3.36%)。然而,75至79岁患者(5.28%)和80岁及以上患者(8.31%)的CABG手术死亡率迅速上升。为了在考虑其他重要风险因素影响后检验年龄对死亡率的独立影响,建立了一个多变量统计模型来确定死亡率的显著独立预测因素。年龄成为24个显著预测因素之一,75岁及以上患者的死亡风险远高于年龄较小者。例如,假设所有其他重要风险因素相同,80岁患者在医院死亡的几率是50岁患者在医院死亡几率的3.25倍。