Hua May, Scales Damon C, Cooper Zara, Pinto Ruxandra, Moitra Vivek, Wunsch Hannah
From the Department of Anesthesiology, Columbia University College of Physicians and Surgeons (M.H., V.M., H.W.); Department of Critical Care Medicine, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada (D.C.S., H.W.); Department of Medicine, Interdepartmental Division of Critical Care (D.C.S.), Department of Anesthesia (H.W.), and Interdisciplinary Department of Critical Care Medicine (H.W.), University of Toronto, Toronto, Ontario, Canada; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Z.C.); and Department of Critical Care Medicine, Sunnybrook Research Institute, Toronto, Ontario, Canada (R.P., H.W.).
Anesthesiology. 2017 Dec;127(6):953-960. doi: 10.1097/ALN.0000000000001884.
Recent reports have raised concerns that public reporting of 30-day mortality after cardiac surgery may delay decisions to withdraw life-sustaining therapies for some patients. The authors sought to examine whether timing of mortality after coronary artery bypass graft surgery significantly increases after day 30 in Massachusetts, a state that reports 30-day mortality. The authors used New York as a comparator state, which reports combined 30-day and all in-hospital mortality, irrespective of time since surgery.
The authors conducted a retrospective cohort study of patients who underwent coronary artery bypass graft surgery in hospitals in Massachusetts and New York between 2008 and 2013. The authors calculated the empiric daily hazard of in-hospital death without censoring on hospital discharge, and they used joinpoint regression to identify significant changes in the daily hazard over time.
In Massachusetts and New York, 24,864 and 63,323 patients underwent coronary artery bypass graft surgery, respectively. In-hospital mortality was low, with 524 deaths (2.1%) in Massachusetts and 1,398 (2.2%) in New York. Joinpoint regression did not identify a change in the daily hazard of in-hospital death at day 30 or 31 in either state; significant joinpoints were identified on day 10 (95% CI, 7 to 15) for Massachusetts and days 2 (95% CI, 2 to 3) and 12 (95% CI, 8 to 15) for New York.
In Massachusetts, a state with a long history of publicly reporting cardiac surgery outcomes at day 30, the authors found no evidence of increased mortality occurring immediately after day 30 for patients who underwent coronary artery bypass graft surgery. These findings suggest that delays in withdrawal of life-sustaining therapy do not routinely occur as an unintended consequence of this type of public reporting.
近期报告引发了人们的担忧,即心脏手术后30天死亡率的公开报告可能会延迟为某些患者做出撤除维持生命治疗的决定。作者试图研究在报告30天死亡率的马萨诸塞州,冠状动脉搭桥手术后死亡时间在30天后是否显著增加。作者将纽约作为对照州,该州报告30天和所有住院死亡率,而不考虑手术时间。
作者对2008年至2013年在马萨诸塞州和纽约州医院接受冠状动脉搭桥手术的患者进行了一项回顾性队列研究。作者计算了未经出院审查的住院死亡的经验性每日风险,并使用连接点回归来确定每日风险随时间的显著变化。
在马萨诸塞州和纽约州,分别有24,864例和63,323例患者接受了冠状动脉搭桥手术。住院死亡率较低,马萨诸塞州有524例死亡(2.1%),纽约州有1,398例(2.2%)。连接点回归未发现两个州中任何一个州在第30天或第31天住院死亡的每日风险有变化;在马萨诸塞州第10天(95%CI,7至15)以及纽约州第2天(95%CI,2至3)和第12天(95%CI,8至15)发现了显著的连接点。
在有长期公开报告心脏手术30天结果历史的马萨诸塞州,作者没有发现接受冠状动脉搭桥手术的患者在30天后立即出现死亡率增加的证据。这些发现表明,作为这种类型公开报告的意外后果,撤除维持生命治疗的延迟并非经常发生。