Hassan E, Leslie J, Martir-Herrero M L
School of Pharmacy, University of Maryland, Baltimore 21211.
Am J Hosp Pharm. 1994 Sep 1;51(17):2143-5.
The compatibility and stability of labetalol hydrochloride in combination with various critical care drugs was evaluated. Labetalol hydrochloride 1.0 mg/mL was combined in 5% dextrose injection with equal volumes of each of the following drugs: dobutamine 2.5 mg/mL (as the hydrochloride salt), dopamine hydrochloride 1.6 mg/mL, morphine sulfate 0.5 mg/mL, nitroglycerin 0.2 mg/mL, and ranitidine 0.6 mg/mL (as the hydrochloride salt). The mixtures were placed in duplicate Y-site administration sets. Visual inspection, pH determination, and high-performance liquid chromatography were performed in duplicate on samples removed at zero, two, and four hours. No change in pH or appearance occurred throughout the study. All drug concentrations remained above 90% of the initial concentration in each combination. Labetalol hydrochloride 1.0 mg/mL and dobutamine 2.5 mg/mL (as the hydrochloride salt), dopamine hydrochloride 1.6 mg/mL, morphine sulfate 0.5 mg/mL, nitroglycerin 0.2 mg/mL, or ranitidine 0.6 mg/mL (as the hydrochloride salt) in 5% dextrose injection were stable and compatible for up to four hours at 20-25 degrees C during simulated Y-site injection.
评估了盐酸拉贝洛尔与各种重症监护药物联合使用时的配伍性和稳定性。将1.0 mg/mL的盐酸拉贝洛尔与5%葡萄糖注射液等量混合，再分别与下列药物等体积混合：2.5 mg/mL的多巴酚丁胺（盐酸盐）、1.6 mg/mL的盐酸多巴胺、0.5 mg/mL的硫酸吗啡、0.2 mg/mL的硝酸甘油以及0.6 mg/mL的雷尼替丁（盐酸盐）。将混合物置于双份Y型给药装置中。在0、2、4小时取出的样品上重复进行外观检查、pH测定和高效液相色谱分析。在整个研究过程中，pH值和外观均未发生变化。每种组合中所有药物浓度均保持在初始浓度的90%以上。在模拟Y型注射过程中，5%葡萄糖注射液中1.0 mg/mL的盐酸拉贝洛尔与2.5 mg/mL的多巴酚丁胺（盐酸盐）、1.6 mg/mL的盐酸多巴胺、0.5 mg/mL的硫酸吗啡、0.2 mg/mL的硝酸甘油或0.6 mg/mL的雷尼替丁（盐酸盐）在20 - 25摄氏度下长达4小时都是稳定且可配伍的。
