Harper D N, McLean A P, Dalrymple-Alford J C
Department of Psychology, University of Canterbury, Christchurch, New Zealand.
Behav Neurosci. 1994 Aug;108(4):691-702. doi: 10.1037//0735-7044.108.4.691.
This study examined the effects of medial septal (MS) and mammillary body (MB) radio-frequency lesions in an automated delayed-matching-to-sample (DMTS) procedure using lever-position stimuli and rats. Memory performance pre- and postsurgery was assessed with a negative exponential decay function fitted to bias-free measures of recognition. Part 1 showed that MS, but not MB or sham-control surgery, impaired DMTS performance. This impairment in the MS group was best characterized as an increase in the rate of forgetting. Part 2 examined the interaction between MS and MB lesion effects and proactive interference arising from responses made on the previous DMTS trial. The results indicated that proactive interference effects were similar for all groups. These results provide further support for the critical role of the MS region in memory function but indicate that damage to this brain region does not disrupt memory function through a heightened sensitivity to proactive interference.
本研究在使用杠杆位置刺激的自动化延迟匹配样本（DMTS）程序中，对内侧隔区（MS）和乳头体（MB）进行射频损伤，并以大鼠为实验对象。通过对无偏差识别测量值拟合负指数衰减函数，评估手术前后的记忆表现。第一部分表明，内侧隔区损伤会损害DMTS表现，而乳头体损伤或假手术对照组则不会。内侧隔区损伤组的这种损害最明显的特征是遗忘率增加。第二部分研究了内侧隔区和乳头体损伤效应之间的相互作用，以及前一次DMTS试验中的反应所产生的前摄干扰。结果表明，所有组的前摄干扰效应相似。这些结果进一步支持了内侧隔区在记忆功能中的关键作用，但表明该脑区受损不会通过对前摄干扰的更高敏感性来破坏记忆功能。
