Mechanisms of vesicle docking and fusion: insights from the nervous system.

作者信息

Pevsner J, Scheller R H

机构信息

Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Beckman Center, Stanford University Medical Center, CA 94305.

出版信息

Curr Opin Cell Biol. 1994 Aug;6(4):555-60. doi: 10.1016/0955-0674(94)90076-0.

DOI:10.1016/0955-0674(94)90076-0

PMID:7986533

Abstract

Upon stimulation of nerve cells, synaptic vesicles fuse with the presynaptic plasma membrane to release neurotransmitter. The biochemical pathway responsible for synaptic-vesicle docking and fusion is now being elucidated. Many of the proteins implicated in this process have homologs elsewhere in the cell. The docking and fusion mechanism discussed in this review may account for the specificity of vesicular trafficking throughout both regulated and constitutive secretory pathways.

摘要