Fujii T, Kato J, Wakabayashi K
Endocrinol Jpn. 1976 Dec;23(6):535-9. doi: 10.1507/endocrj1954.23.535.
Synthetic LHRH, at a dose of 5 mug/kg, induced a marked increase in the serum LH level but a marked decrease in the serum prolactin level when injected iv to normal adult female rats on the day of estrus. In adrogenized adult rats which had been showing persistent estrous vaginal smears, a less marked increase in the serum LH level was shown following injection of LHRH. Prolactin level decreased only slightly in these animals. Control level of serum prolactin in normal estrous and androgenized rats were 4.95 +/- 0.35 and 5.42 +/- 0.65 mIU/ml, respectively. Thyroidectomized-normal cycling rats responded to LHRH with a slight decrease in the serum prolactin level when injected on the day of diestrus. Prolactin level increased, however, 5 min after LHRH injection in thyroidectomized-androgenized adult rats, which were thyroidectomized at the age 4, 6 or 10-12 weeks and have retained a low prolactin level similar to that in the diestrous stage of normal cycling rats thereafter. The present results suggest that regulatory system of prolactin secretion became labile by androgenization and this status led to the release of prolactin by LHRH treatment after thyroidectomy.
在发情日给正常成年雌性大鼠静脉注射剂量为5微克/千克的合成促黄体生成素释放激素（LHRH）时，可使血清促黄体生成素（LH）水平显著升高，但血清催乳素水平显著降低。在持续出现动情期阴道涂片的雄激素化成年大鼠中，注射LHRH后血清LH水平升高不太明显。这些动物的催乳素水平仅略有下降。正常动情期和雄激素化大鼠的血清催乳素对照水平分别为4.95±0.35和5.42±0.65毫国际单位/毫升。在间情期给甲状腺切除的正常发情周期大鼠注射LHRH后，血清催乳素水平略有下降。然而，在4、6或10 - 12周龄时进行甲状腺切除且此后催乳素水平一直维持在与正常发情周期大鼠间情期相似的低水平的甲状腺切除-雄激素化成年大鼠中，注射LHRH 5分钟后催乳素水平升高。目前的结果表明，雄激素化使催乳素分泌的调节系统变得不稳定，这种状态导致甲状腺切除后经LHRH处理释放催乳素。
