Drancourt M, McNeil M M, Brown J M, Lasker B A, Maurin M, Choux M, Raoult D
Laboratoire de Microbiologie Clinique, C.H.U. La Timone, Marseille, France.
Clin Infect Dis. 1994 Aug;19(2):258-62. doi: 10.1093/clinids/19.2.258.
A brain abscess complicated antineoplastic chemotherapy for a primary cerebral rhabdoid tumor in an immunocompromised boy. Culture of purulent exudate obtained by surgical puncture of an intracranial hematoma yielded a gram-positive microorganism initially identified as a Rhodococcus species by conventional biochemical analysis; however, the isolate was subsequently identified as Gordona terrae by ribosomal DNA analysis. To our knowledge, this is the third case of human infection caused by G. terrae and the first case of a brain abscess due to this organism. As this case demonstrates, this species may cause opportunistic invasive infection in severely immunocompromised patients. The identity of clinical isolates believed to be G. terrae should be confirmed by molecular methods until better species-specific phenotypic markers become available.
一名免疫功能低下男孩因原发性脑横纹肌样瘤接受抗肿瘤化疗后并发脑脓肿。通过对颅内血肿进行外科穿刺获取的脓性渗出物培养,经传统生化分析最初鉴定出一种革兰氏阳性微生物为红球菌属;然而,随后通过核糖体DNA分析将该分离株鉴定为地戈登菌。据我们所知,这是第三例由地戈登菌引起的人类感染病例,也是首例由此种微生物导致的脑脓肿病例。正如本病例所示,该菌种可能在严重免疫功能低下患者中引起机会性侵袭性感染。在获得更好的物种特异性表型标志物之前,对于疑似地戈登菌的临床分离株,应通过分子方法进行鉴定。