Schiffmann S
Bull Mem Acad R Med Belg. 1993;148(10):370-9.
In human, cholecystokinin-immunoreactive nerve fibres are abundantly distributed in the ventral striatum and in other regions of the basal ganglia interconnected with the limbic system. This suggests that this neuropeptide is involved in the initiation of movements following emotional stimuli. The demonstration of an extended cholecystokinin expression in cortico-, thalamo-, and nigrostriatal pathways using in situ hybridization indicates that this neuromodulator may have some important functions either in motor, cognitive or limbic systems. In addition, disruption of the nigrostriatal dopaminergic pathway induces the expression of cholecystokinin in the striatal neurons. This new example of functional plasticity suggests that dopamine exerts a negative tonus on cholecystokinin expression. Finally, cholecystokinin expression is increased in meso-limbic and nigrostriatal dopaminergic neurons of schizophrenic patients.
在人类中，胆囊收缩素免疫反应性神经纤维大量分布于腹侧纹状体以及与边缘系统相互连接的基底神经节的其他区域。这表明这种神经肽参与了情绪刺激后运动的启动。利用原位杂交技术在皮质 - 丘脑 - 黑质纹状体通路中证实胆囊收缩素表达的扩展，表明这种神经调质可能在运动、认知或边缘系统中具有一些重要功能。此外，黑质纹状体多巴胺能通路的破坏会诱导纹状体神经元中胆囊收缩素的表达。这种功能可塑性的新例子表明多巴胺对胆囊收缩素的表达具有负性张力作用。最后，精神分裂症患者的中脑边缘和黑质纹状体多巴胺能神经元中胆囊收缩素的表达增加。
