Bergmann P, Nijs-De Wolf N, Karmali R, Pepersack T, Corvilain J
Laboratoire de Médecine expérimentale de l'Hôpital Brugmann, Université libre de Bruxelles.
Bull Mem Acad R Med Belg. 1993;148(11-12):401-7.
Several research groups have identified a "parathyroid hormone related peptide" (PTHrP) in tumors of patients presenting with the hypercalcemia of malignancy. The N-terminal domain of this peptide has a high degree of homology with that of the parathyroid hormone (PTH) and shares the PTH biological activities. PTHrP has later been identified in several foetal and adult normal tissues: for instance, it is expressed and secreted by foetal parathyroid glands, and it plays an important role in placental calcium transport; it is also expressed in the uterus of pregnant rats; there it could have a paracrine action on myometer relaxation. We have shown that PTHrP is present in and released in culture by foetal rat long bones. The mRNA of PTHrP is expressed in the periosteal cells of these foetal bones. The local expression and secretion of PTHrP in bone suggests that this new peptide could have a local role in the regulation of bone remodeling and development.
几个研究小组在患有恶性肿瘤高钙血症患者的肿瘤中发现了一种“甲状旁腺激素相关肽”（PTHrP）。该肽的N端结构域与甲状旁腺激素（PTH）的N端结构域具有高度同源性，并具有PTH的生物学活性。后来在几种胎儿和成人正常组织中也发现了PTHrP：例如，它由胎儿甲状旁腺表达和分泌，在胎盘钙转运中起重要作用；它也在怀孕大鼠的子宫中表达；在那里它可能对子宫肌层舒张起旁分泌作用。我们已经证明PTHrP存在于胎鼠长骨中并在培养中释放。PTHrP的mRNA在这些胎儿骨骼的骨膜细胞中表达。PTHrP在骨中的局部表达和分泌表明这种新肽可能在骨重塑和发育的调节中起局部作用。
