Duclos P, Tepper M L, Weber J, Marusyk R G
Childhood Immunization Division, Bureau of Communicable Disease Epidemiology, Ottawa, ON.
Can J Public Health. 1994 Jul-Aug;85(4):278-81.
A study of the seroprevalence of measles- and rubella-specific antibodies among military recruits in Canada in 1991 was undertaken to: 1) determine the proportion of military recruits who are measles and/or rubella seropositive when they enter the military; 2) detect general problems in the immune coverage in the young adult population; and 3) determine the proportion of measles seronegativity attributable to non-response, waning immunity or lack of exposure to either the disease or the vaccine. One initial blood sample was collected from all 399 recruits enrolled in basic training during the month of January 1991, prior to immunization with measles-mumps-rubella vaccine (MMR). Another sample was obtained from 354 of these recruits 3 to 5 weeks following this immunization. Only 18 (4.5%) recruits had negative measles-specific neutralization on the first sample. Only 12 (3.0%) recruits had negative measles-specific EIA on the first sample. All recruits had neutralization titres 40 or higher on the second sample. A total of 43 (10.8%) individuals had negative results for rubella EIA before immunization, 35 of which (81.4%) tested positive on the second sample.
1991年对加拿大新兵中麻疹和风疹特异性抗体的血清流行率进行了一项研究，目的是：1）确定入伍时麻疹和/或风疹血清呈阳性的新兵比例；2）发现年轻成人人群免疫覆盖方面的普遍问题；3）确定因无反应、免疫力减弱或未接触疾病或疫苗而导致的麻疹血清阴性比例。1991年1月，在所有399名参加基础训练的新兵接种麻疹-腮腺炎-风疹疫苗（MMR）之前，采集了一份初始血样。在接种疫苗3至5周后，从其中354名新兵身上获取了另一份血样。在第一个样本中，只有18名（4.5%）新兵的麻疹特异性中和试验呈阴性。在第一个样本中，只有12名（3.0%）新兵的麻疹特异性酶免疫测定呈阴性。所有新兵在第二个样本中的中和滴度均为40或更高。共有43名（10.8%）个体在免疫前风疹酶免疫测定结果为阴性，其中35名（81.4%）在第二个样本中检测呈阳性。
