Cooper A J, Swamy G N
University of Western Ontario, London.
Can J Psychiatry. 1994 Sep;39(7):436-8. doi: 10.1177/070674379403900709.
It has been suggested that the administration of androgens to paranoid schizophrenics who castrate themselves because of religious delusions and sexual guilt might exacerbate the psychosis and increase the risk of further self-mutilation. We administered testosterone enanthate to such a case intermittently during his 12 week hospital stay and studied simultaneously, psychopathology (Brief Psychiatric Rating Scale and clinical assessment), hormone levels and sexual behaviours. Sexual behaviours increased in line with increased serum testosterone levels; psychopathology declined. Following his discharge, he was managed on a regime of phenothiazines and monthly testosterone injections. After one year, he was enjoying normal heterosexual activities (without guilt) although his extreme religiosity had not declined.
有人提出，对于因宗教妄想和性内疚而自行阉割的偏执型精神分裂症患者使用雄激素，可能会加重精神病症状，并增加进一步自我伤害的风险。我们在一名此类患者住院12周期间间歇性地给他注射庚酸睾酮，并同时研究了精神病理学（简明精神病评定量表和临床评估）、激素水平和性行为。性行为随着血清睾酮水平的升高而增加；精神病理学症状有所减轻。出院后，他接受吩噻嗪类药物治疗并每月注射睾酮。一年后，他能够正常进行异性恋活动（没有内疚感），尽管他极端的宗教狂热并没有减退。
