Xing X, Meng X, Zhan Z
PUMC Hospital, CAMS, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1994 Apr;16(2):116-21.
This article report a study of 23 cases of hypercalcemia crisis resulting from primary hyperparathyroidism (18 cases), carcinoma (4 cases) and vitamin D intoxication (1 case). In addition to the symptoms of primary diseases, the patients with hypercalcemia crisis often had anorexia, nausea, vomiting, polydipsia, polyuria, psychoneurotic symptoms, arrhthmia. The severity of the symptoms was proportional to the degree of hypercalcimia. Serum calcium concentration of patients in hypercalcemia crisis should be equal or higher than 3.75 mmol/L (15 mg/dl) or serum ionized calcium higher than 1.88 mmol/L. Treatment hypercalcemia crisis consisted of rapidly lowering the serum calcium level by various measures while actively treating the primary diseases. Our experience is to supply normal saline intravenously or orally to increase the extracellular fluid and to enhance excretion of the urine calcium by administrating furosemide. In this paper, serum calcium concentration of 5 patients with hypercalcemia crisis treated with salmen calcitonin was reduced in varying degrees. The above mentioned treatment would be beneficial to the alleviation of the crisis and the preparation for operative treatment.
本文报告了一项对23例高钙血症危象患者的研究，这些患者分别由原发性甲状旁腺功能亢进（18例）、癌症（4例）和维生素D中毒（1例）引起。除了原发性疾病的症状外，高钙血症危象患者常伴有厌食、恶心、呕吐、多饮、多尿、精神神经症状、心律失常。症状的严重程度与高钙血症的程度成正比。高钙血症危象患者的血清钙浓度应等于或高于3.75 mmol/L（15 mg/dl），或血清离子钙高于1.88 mmol/L。高钙血症危象的治疗包括通过各种措施迅速降低血清钙水平，同时积极治疗原发性疾病。我们的经验是静脉或口服补充生理盐水以增加细胞外液，并通过给予呋塞米增强尿钙排泄。本文中，5例接受鲑鱼降钙素治疗的高钙血症危象患者的血清钙浓度有不同程度的降低。上述治疗将有助于缓解危象并为手术治疗做准备。
