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[人甲状旁腺组织移植到裸鼠后人类白细胞抗原的改变]

[Alteration of human leukocyte antigens in human parathyroid tissues after transplantation into nude mice].

作者信息

Gao Z, Zhu Y

机构信息

PUMC Hospital, CAMS, Beijing.

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1994 Apr;16(2):144-6.

PMID:7987943
Abstract

Human parathyroid (PTG) tissues from cadaver (C-PTG), 20-28 wk fetus (F-PTG) and PTG adenoma (A-PTG) were transplanted into the kidney subcapsular spaces of Balb/C nude mice as interim host. Dynamic changes in the amount of human leukocyte antigens (HLA) in human PTG grafts within the transplantation period were observed. The results showed that during 100 days of interim hosting, no obvious changes in the amount of tissue HLA class I antigens occurred, but the amount of tissue HLA class II antigens were significantly reduced, The changes of HLA antigens in the different types of donor human PTG tissues were compared.

摘要

将来自尸体的人甲状旁腺(C-PTG)、20 - 28周胎儿的甲状旁腺(F-PTG)和甲状旁腺腺瘤(A-PTG)移植到Balb/C裸鼠的肾被膜下间隙作为临时宿主。观察移植期内人甲状旁腺移植物中人类白细胞抗原(HLA)数量的动态变化。结果显示,在100天的临时宿主期内,组织HLA I类抗原数量无明显变化,但组织HLA II类抗原数量显著减少。比较了不同类型供体人甲状旁腺组织中HLA抗原的变化。

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