Maddrey W C
University of Texas Southwestern Medical Center at Dallas.
Gastroenterol Clin North Am. 1994 Sep;23(3):429-35.
A variety of viruses cause many of the disorders that are recognized as acute and chronic liver diseases. Remarkable scientific advances achieved during the past two decades have lead to readily available accurate diagnostic tests for hepatitis viruses designated A through E. Effective vaccines have been developed to prevent hepatitis B and, more recently, hepatitis A. Heightened understanding of the pathogenesis of chronic hepatitis caused by hepatitis B and C suggests several promising therapeutic approaches. Interferon is the sole drug yet proven to be effective in the treatment of some patients with chronic hepatitis B and C. Newer antiviral agents that will be used alone or in combination are under development.
多种病毒可引发许多被视为急慢性肝病的病症。在过去二十年中取得的显著科学进展，已带来了针对从甲型到戊型肝炎病毒的现成且准确的诊断检测方法。现已研发出有效的疫苗来预防乙型肝炎，最近还可预防甲型肝炎。对由乙型和丙型肝炎所致慢性肝炎发病机制的深入了解，提示了几种有前景的治疗方法。干扰素是唯一已被证明对部分慢性乙型和丙型肝炎患者有效的药物。正在研发将单独使用或联合使用的新型抗病毒药物。
