Kollef M H
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Heart Lung. 1994 Sep-Oct;23(5):363-7.
Antibiotics represent one of the most commonly prescribed medical therapies for hospitalized patients. The practice of "spiralling empiricism" has increasingly led to the unnecessary administration of antibiotics, resulting in the emergence of infections with antibiotic-resistant bacteria that are associated with increased rates of patient mortality. Ventilator-associated pneumonia due to antibiotic-resistant bacteria has become recognized as an important problem resulting from prior antibiotic exposure. Health professionals must be aware of this problem and avoid the unnecessary administration of these drugs. Future research efforts should be aimed at improving our ability to diagnose and exclude infections and to develop better strategies for antibiotic administration in the intensive care unit setting.
抗生素是住院患者最常用的药物治疗手段之一。“螺旋式经验主义”做法日益导致抗生素的不必要使用，从而出现了耐抗生素细菌感染，这与患者死亡率上升有关。由耐抗生素细菌引起的呼吸机相关性肺炎已被公认为先前使用抗生素所导致的一个重要问题。卫生专业人员必须意识到这个问题，并避免不必要地使用这些药物。未来的研究工作应致力于提高我们诊断和排除感染的能力，以及制定在重症监护病房环境中更好的抗生素给药策略。
