Weller R A, Kapadia P, Weller E B, Fristad M, Lazaroff L B, Preskorn S H
Department of Psychiatry, Ohio State University, Columbus 43210.
J Affect Disord. 1994 Aug;31(4):247-52. doi: 10.1016/0165-0327(94)90100-7.
Family psychiatric histories of 63 inpatient children with major depressive disorder (MDD) and 63 matched inpatient psychiatric controls were compared. MDD, anxiety disorders, somatization disorder and antisocial personality disorder (ASP) were significantly more common (P < 0.05) in the family histories of MDD probands. When family histories of depressed/anxious (D/A) versus depressed/behavior disordered (D/B) children were compared, the D/B group had more alcohol abuse (P < 0.05) and antisocial personality disorder (P < 0.08) than the D/A group. This report supports findings from earlier studies and suggests mood and anxiety disorders are increased in families of children with MDD.
比较了63名患有重度抑郁症（MDD）的住院儿童和63名匹配的住院精神科对照儿童的家族精神病史。MDD先证者的家族病史中，MDD、焦虑症、躯体化障碍和反社会人格障碍（ASP）明显更为常见（P<0.05）。当比较抑郁/焦虑（D/A）儿童与抑郁/行为障碍（D/B）儿童的家族病史时，D/B组的酒精滥用（P<0.05）和反社会人格障碍（P<0.08）比D/A组更多。本报告支持早期研究的结果，并表明MDD儿童家庭中情绪和焦虑障碍有所增加。
