利用碳-11-SCH 39166和碳-11-NNC 756对人脑多巴胺D1受体进行的正电子发射断层扫描（PET）研究。

PET studies on dopamine D1 receptors in the human brain with carbon-11-SCH 39166 and carbon-11-NNC 756.

作者信息

Laihinen A O, Rinne J O, Ruottinen H M, Någren K A, Lehikoinen P K, Oikonen V J, Ruotsalainen U H, Rinne U K

机构信息

Department of Neurology, University of Turku, Finland.

出版信息

J Nucl Med. 1994 Dec;35(12):1916-20.

PMID:7989969

Abstract

UNLABELLED

PET studies were carried out on brain dopamine D1 receptors using two new ligands, [11C]SCH 39166 and [11C]NNC 756.

METHODS

Four normal subjects and eight predominantly unilateral patients with early Parkinson's disease were investigated. Each of them underwent both a PET scan with [11C]SCH 39166 and one with [11C]NNC 756. A dose of about 185 MBq (5 mCi) of these ligands was administered intravenously and a dynamic PET scan with an ECAT 931/08 PET camera was carried out. Ratios between the striatal and cerebellar uptake of these compounds were calculated.

RESULTS

Both [11C]SCH 39166 and [11C]NNC 756 accumulated in the striatum. There was also some neocortical binding; 75% of the striatal value in the case of [11C]SCH 39166 and 60% with [11C]NNC 756 which displayed higher (p < 0.01) uptake in the striatum than [11C]SCH 39166. There were no significant side-to-side differences in the controls nor in the parkinsonian patients.

CONCLUSIONS

These results imply that both [11C]SCH 39166 and [11C]NNC 756 can be used in PET studies for the visualization and quantification of dopamine D1 receptors. Since [11C]NNC 756 has a significantly better signal-to-noise ratio in the striatum than [11C]SCH 39166, it seems to offer definite advantages for studies of D1 receptors.

摘要

未标记

使用两种新的配体[11C]SCH 39166和[11C]NNC 756对脑多巴胺D1受体进行了正电子发射断层扫描（PET）研究。

方法

对4名正常受试者和8名主要为单侧患病的早期帕金森病患者进行了研究。他们每人都接受了一次用[11C]SCH 39166的PET扫描和一次用[11C]NNC 756的PET扫描。静脉注射约185 MBq（5 mCi）的这些配体，并使用ECAT 931/08 PET相机进行动态PET扫描。计算了这些化合物在纹状体和小脑摄取之间的比率。

结果

[11C]SCH 39166和[11C]NNC 756都在纹状体中蓄积。也有一些新皮质结合；[11C]SCH 39166的新皮质结合为纹状体值的75%，[11C]NNC 756的为60%，[11C]NNC 756在纹状体中的摄取高于[11C]SCH 39166（p < 0.01）。对照组和帕金森病患者两侧之间均无显著差异。