Lemne C, de Faire U, Fagrell B
Department of Medicine II, Karolinska Hospital, Stockholm, Sweden.
J Hum Hypertens. 1994 Aug;8(8):559-63.
It has recently been shown that the reactivity of total (= thermoregulatory) and nutritional (= capillary) skin microcirculation differs in hypertension and normotension (NT) with a reduced stress response in hypertension. The present study investigated skin microcirculation in 40 patients with borderline hypertension (BHT) and 38 NT controls. Capillary blood flow (CBV, dynamic capillaroscopy) and subpapillary thermoregulatory flow (Laser Doppler fluxmetry, LDF) was measured at rest, after arterial occlusion and during and after a mental stress test. Resting CBV (0.48 vs. 0.50 mm/s) and LDF (3.19 vs. 3.06 AU) were equal in the two groups and no difference was found in postocclusive hyperaemia response. Reactivity to mental stress was similar in both groups with a significant increase in LDF (45% and 39%) and a significant decrease in CBV (35% and 30%). In nonsmokers the BHT group tended to increase less in LDF (50% vs. 72%) and decrease slightly more in CBV (35% vs. 28%) than the NT group. No such difference was seen in smokers. Mental stress induces opposite reactions in total and nutritional skin microcirculation both in borderline hypertensives and normotensives. There were no significant differences in reactivity between the two groups, possibly due to the alleviated responses seen in smokers in both groups.
最近研究表明，高血压患者与血压正常者相比，其总的（即体温调节性的）和营养性的（即毛细血管性的）皮肤微循环反应性存在差异，高血压患者的应激反应降低。本研究调查了40例临界高血压患者和38例血压正常对照者的皮肤微循环。在静息状态、动脉闭塞后以及精神应激试验期间和之后，测量毛细血管血流量（CBV，动态毛细血管显微镜检查）和乳头下体温调节血流量（激光多普勒血流仪，LDF）。两组的静息CBV（0.48对0.50毫米/秒）和LDF（3.19对3.06 AU）相等，闭塞后充血反应无差异。两组对精神应激的反应相似，LDF显著增加（45%和39%），CBV显著降低（35%和30%）。在不吸烟者中，临界高血压组LDF的增加幅度（50%对72%）比血压正常组小，CBV的降低幅度（35%对28%）比血压正常组略大。吸烟者中未观察到这种差异。精神应激在临界高血压患者和血压正常者中均引起总的和营养性皮肤微循环的相反反应。两组之间的反应性无显著差异，这可能是由于两组吸烟者的反应均有所减轻。
