Deguchi K, Yokota N, Koguchi M, Suzuki Y, Fukayama S, Ishihara R, Oda S, Tanaka S, Nakane Y, Fukumoto T
Section of Studies, Tokyo Clinical Research Center.
Jpn J Antibiot. 1994 Sep;47(9):1186-91.
In order to examine antimicrobial activities of fosfomycin (FOM), the minimum inhibitory concentrations (MICs) of FOM and those of control drugs were determined against Streptococcus pneumoniae and Haemophilus influenzae isolated from sinusitis patients from September to November, 1993, and the following results were obtained. 1. Among 50 S. pneumoniae strains tested, there were 10 strains (20.0%) of benzylpenicillin (PCG)-insensitive S. pneumoniae (PISP) and 2 strains (4.0%) of PCG-resistant S. pneumoniae (PRSP); but the MIC distributions of FOM among the PISPs and the PRSPs were almost identical to those among the PCG-susceptible S. pneumoniae (PSSP). 2. There were 12 strains (24.0%) of beta-lactamase producing strains among 50 strains of H. influenzae tested, but the FOM's MIC distribution among these strains was almost identical to that among beta-lactamase non-producing strains. 3. The results obtained on the MIC90s of FOM against S. pneumoniae and H. influenzae suggest that the nebulization treatment with FOM nasal preparation satisfies the condition "above the MIC".
为检测磷霉素（FOM）的抗菌活性，测定了FOM及对照药物对1993年9月至11月从鼻窦炎患者分离出的肺炎链球菌和流感嗜血杆菌的最低抑菌浓度（MIC），结果如下。1. 在检测的50株肺炎链球菌中，有10株（20.0%）对苄青霉素（PCG）不敏感的肺炎链球菌（PISP）和2株（4.0%）对PCG耐药的肺炎链球菌（PRSP）；但FOM在PISP和PRSP中的MIC分布与对PCG敏感的肺炎链球菌（PSSP）中的分布几乎相同。2. 在检测的50株流感嗜血杆菌中，有12株（24.0%）产β-内酰胺酶菌株，但FOM在这些菌株中的MIC分布与不产β-内酰胺酶菌株中的分布几乎相同。3. FOM对肺炎链球菌和流感嗜血杆菌的MIC90结果表明，FOM鼻用制剂雾化治疗满足“高于MIC”的条件。
