Vege D S, Soman C S, Joshi U A, Ganesh B, Yadav J N
Department of Pathology, Tata Memorial Hospital, Parel, Bombay.
J Surg Oncol. 1994 Dec;57(4):273-6. doi: 10.1002/jso.2930570414.
Immunohistochemical staining was performed on 145 biopsies with a diagnosis of undifferentiated or poorly differentiated tumor in order to classify them into lymphoid, epithelial, or mesenchymal in origin. It was possible to arrive at a histogenetic diagnosis on immunostaining in 85.5% of cases. Immunostaining confirmed the diagnosis in 32.4% and contributed to diagnosis in 53.1%. Malignant lymphoma was the most common diagnosis (35.9%), followed by carcinoma (23.4%). A panel of antibodies consisting of anti-common leucocyte antigen (LCA), anti-epithelial membrane antigen (EMA), anti-cytokeratin (CK), anti-low to intermediate molecular weight cytokeratin (CAM 5.2), anti-S-100 protein (S-100), and anti-vimentin (VM) may resolve, to a large extent, some of the common diagnostic problems.
对145例诊断为未分化或低分化肿瘤的活检组织进行免疫组织化学染色，以便将它们按起源分类为淋巴样、上皮样或间充质样。85.5%的病例通过免疫染色能够得出组织发生学诊断。免疫染色确诊32.4%，辅助诊断53.1%。恶性淋巴瘤是最常见的诊断（35.9%），其次是癌（23.4%）。一组由抗共同白细胞抗原（LCA）、抗上皮膜抗原（EMA）、抗细胞角蛋白（CK）、抗低至中分子量细胞角蛋白（CAM 5.2）、抗S-100蛋白（S-100）和抗波形蛋白（VM）组成的抗体，在很大程度上可解决一些常见的诊断问题。
